Single-Minded Homolog 1 (SIM1) Antibody

SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis, it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or mental retardation of Down syndrome.

Target	Single-Minded Homolog 1 (SIM1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/2000, IHC-P: 1/250. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SIM1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P81133 (UniProt, ExPASy)
UniProt Secondary AC	Q5TDP7
UniProt Entry Name	SIM1_HUMAN
Gene Symbol	SIM1
GeneID	6492
OMIM	603128
HGNC	10882
KEGG	hsa:6492
String	9606.ENSP00000358210
Molecular Weight	Calculated MW: 85.5 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Zebrafish and Drosophila SIM1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Single-Minded Homolog 1 (SIM1)

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