NAD-Dependent Protein Deacetylase Sirtuin-3, Mitochondrial (SIRT3) Antibody
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Catalogue No: abx032747
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US$326.25
(Size: 80 µl)
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Datasheet SDS
SIRT3 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The SIRT3 is included in class I of the sirtuin family.
Research Articles on NAD-Dependent Protein Deacetylase Sirtuin-3, Mitochondrial (SIRT3)
| Target | NAD-Dependent Protein Deacetylase Sirtuin-3, Mitochondrial (SIRT3) |
| Research Area | Signal Transduction |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 250-279 amino acids from the C-terminal region of human SIRT3. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q9NTG7 (UniProt, ExPASy) |
| UniProt Secondary AC | B7Z5U6, Q9Y6E8 |
| UniProt Entry Name | SIR3_HUMAN |
| NCBI Accession | NP_001017524.1 NP_036371.1 |
| String | 9606.ENSP00000372191 |
| Molecular Weight | Calculated MW: 43.6 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |