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NAD-Dependent Protein Deacetylase Sirtuin-3, Mitochondrial (SIRT3) Antibody
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Catalogue No: abx005514
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US$217.50
(Size: 20 µl)
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SIRT3 Antibody is a Rabbit Polyclonal antibody against SIRT3. This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene.
Research Articles on NAD-Dependent Protein Deacetylase Sirtuin-3, Mitochondrial (SIRT3)
| Target | NAD-Dependent Protein Deacetylase Sirtuin-3, Mitochondrial (SIRT3) |
| Research Area | Signal Transduction |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC, IF/ICC, IP |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200, IP: 0.5 µg - 4 µg antibody per 200 µg - 400 µg extracts of whole cells. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Synthetic peptide corresponding to SIRT3. The exact sequence is proprietary. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9NTG7 (UniProt, ExPASy) |
| UniProt Secondary AC | B7Z5U6, Q9Y6E8 |
| UniProt Entry Name | SIR3_HUMAN |
| Gene Symbol | SIRT3 |
| GeneID | 23410 |
| NCBI Accession | NP_036371.1 |
| String | 9606.ENSP00000372191 |
| Molecular Weight | Calculated MW: 44 kDa Observed MW: 28/44 kDa |
| Buffer | PBS, pH 7.3, containing 0.09% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |