S-Phase Kinase Associated Protein 1 (SKP1) Antibody

This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins.This protein binds directly to the F-box motif found in F-box proteins.SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome.Specific F-box proteins recognize different target protein (s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development.Studies have also characterized the protein as an RNA polymerase II elongation factor.Alternative splicing of this gene results in two transcript variants.A related pseudogene has been identified on chromosome 7.

Target	S-Phase Kinase Associated Protein 1 (SKP1)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human SKP1 expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P63208 (UniProt, ExPASy)
UniProt Secondary AC	D3DQ97, D3DQ98, P34991, Q8TAY2
UniProt Entry Name	SKP1_HUMAN
Gene Symbol	SKP1
GeneID	6500
OMIM	601434
HGNC	10899
KEGG	hsa:6500
Ensembl	ENSG00000113558
String	9606.ENSP00000231487
Molecular Weight	19 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on S-Phase Kinase Associated Protein 1 (SKP1)

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