Sodium/Calcium Exchanger 1 (SLC8A1) Antibody
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Catalogue No: abx034167
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US$326.25
(Size: 80 µl)
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Datasheet SDS
Sodium/Calcium Exchanger 1 (SLC8A1) Antibody is a Rabbit polyclonal against Sodium/Calcium Exchanger 1 (SLC8A1). In cardiac myocytes, Ca (2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca (2+) centration during contraction is primarily due to release of Ca (2+) from intracellular stores. However, some Ca (2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca (2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca (2+) that entered across the sarcolemma must be extruded from the cell. The Na (+) Ca (2+) exchanger is the primary mechanism by which the Ca (2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.
Research Articles on Sodium/Calcium Exchanger 1 (SLC8A1)
| Target | Sodium/Calcium Exchanger 1 (SLC8A1) |
| Research Area | Signal Transduction |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 296-325 amino acids from the central region of Human Sodium/Calcium Exchanger 1 (SLC8A1). |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P32418 (UniProt, ExPASy) |
| UniProt Entry Name | NAC1_HUMAN |
| Gene Symbol | SLC8A1 |
| NCBI Accession | NP_001106271.1 NP_001106272.1 NP_001106273.1 NP_001239553.1 NP_066920.1 |
| KEGG | hsa:6546 |
| String | 9606.ENSP00000384763 |
| Molecular Weight | Calculated MW: 109 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Rat and Cow SLC8A1. |
| Concentration | 0.5 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |