SMAD Family Member 1 Phospho-Ser206 (SMAD1 pS206) Antibody

Catalogue No: abx000346
Price: £230.00
(Size: 50 µl)
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SMAD1 (pS206) Antibody is a Rabbit Polyclonal antibody against SMAD1 (pS206). The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.

Target SMAD Family Member 1 Phospho-Ser206 (SMAD1 pS206)
Clonality Polyclonal
Target Modification Ser206
Modification Phosphorylation
Reactivity Human, Mouse, Rat
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding S206 of human SMAD1.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q15797 (UniProt, ExPASy)
UniProt Secondary AC A8KAJ0, D3DNZ9, Q16636, Q9UFT8
UniProt Entry Name SMAD1_HUMAN
Gene Symbol SMAD1
GeneID 4086
KEGG hsa:4086
String 9606.ENSP00000426568
Molecular Weight Calculated MW: 15 kDa, 52 kDa
Observed MW: 60 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 0.5 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on SMAD Family Member 1 Phospho-Ser206 (SMAD1 pS206)

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