SMAD Family Member 1 Phospho-Ser206 (SMAD1 pS206) Antibody

SMAD1 (pS206) Antibody is a Rabbit Polyclonal antibody against SMAD1 (pS206). The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.

Target	SMAD Family Member 1 Phospho-Ser206 (SMAD1 pS206)
Clonality	Polyclonal
Target Modification	Ser206
Modification	Phosphorylation
Reactivity	Human, Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic phosphorylated peptide around S206 of human Smad1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q15797 (UniProt, ExPASy)
UniProt Secondary AC	A8KAJ0, D3DNZ9, Q16636, Q9UFT8
UniProt Entry Name	SMAD1_HUMAN
Gene Symbol	SMAD1
GeneID	4086
NCBI Accession	NP_005891.1
KEGG	hsa:4086
String	9606.ENSP00000426568
Molecular Weight	Calculated MW: 52 kDa Observed MW: 60 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on SMAD Family Member 1 Phospho-Ser206 (SMAD1 pS206)

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