Mothers Against Decapentaplegic Homolog 2 Phospho-Ser467 (SMAD2 pS467) Antibody

SMAD2 (pS467) Antibody is a Rabbit Polyclonal antibody against SMAD2 (pS467). The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.

Target	Mothers Against Decapentaplegic Homolog 2 Phospho-Ser467 (SMAD2 pS467)
Clonality	Polyclonal
Target Modification	Ser467
Modification	Phosphorylation
Reactivity	Human, Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic phosphorylated peptide around S467 of human Smad2.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q15796 (UniProt, ExPASy)
UniProt Entry Name	SMAD2_HUMAN
Gene Symbol	SMAD2
GeneID	4087
NCBI Accession	NP_001003652.1
KEGG	hsa:4087
String	9606.ENSP00000262160
Molecular Weight	Calculated MW: 52 kDa Observed MW: 60 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Mothers Against Decapentaplegic Homolog 2 Phospho-Ser467 (SMAD2 pS467)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue