Mothers Against Decapentaplegic Homolog 4 (SMAD4) Antibody
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Catalogue No: abx015994
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US$427.75
(Size: 100 µl)
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Datasheet SDS
Common mediator of signal transduction by TGF-beta (transforming growth factor) superfamily; SMAD4 is the common SMAD (co-SMAD).Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription.May act as a tumor suppressor. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.
Research Articles on Mothers Against Decapentaplegic Homolog 4 (SMAD4)
| Target | Mothers Against Decapentaplegic Homolog 4 (SMAD4) |
| Clonality | Monoclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IHC, IF/ICC, FCM |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human SMAD4 expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q13485 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K405 |
| UniProt Entry Name | SMAD4_HUMAN |
| Gene Symbol | SMAD4 |
| GeneID | 4089 |
| OMIM | 114500 |
| HGNC | 6770 |
| KEGG | hsa:4089 |
| Ensembl | ENSG00000141646 |
| String | 9606.ENSP00000341551 |
| Molecular Weight | 65 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |