Mothers Against Decapentaplegic Homolog 6 (SMAD6) Antibody
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Catalogue No: abx015995
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US$427.75
(Size: 100 µl)
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Datasheet SDS
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1.SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD.Binds to regulatory elements in target promoter regions.Tissue specificity: Ubiquitous in various organs, with higher levels in lung.Isoform B is up-regulated in diseased heart tissue.
Research Articles on Mothers Against Decapentaplegic Homolog 6 (SMAD6)
| Target | Mothers Against Decapentaplegic Homolog 6 (SMAD6) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human SMAD6 expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | O43541 (UniProt, ExPASy) |
| UniProt Secondary AC | A9J6M5, O43654, Q15799, Q7Z7L4, Q96E31, Q9UKZ3 |
| UniProt Entry Name | SMAD6_HUMAN |
| Gene Symbol | SMAD6 |
| GeneID | 4091 |
| OMIM | 602931 |
| HGNC | 6772 |
| KEGG | hsa:4091 |
| Ensembl | ENSG00000137834 |
| String | 9606.ENSP00000288840 |
| Molecular Weight | 53 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |