Mothers Against Decapentaplegic Homolog 6 (SMAD6) Antibody

Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1.SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD.Binds to regulatory elements in target promoter regions.Tissue specificity: Ubiquitous in various organs, with higher levels in lung.Isoform B is up-regulated in diseased heart tissue.

Target	Mothers Against Decapentaplegic Homolog 6 (SMAD6)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human SMAD6 expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O43541 (UniProt, ExPASy)
UniProt Secondary AC	A9J6M5, O43654, Q15799, Q7Z7L4, Q96E31, Q9UKZ3
UniProt Entry Name	SMAD6_HUMAN
Gene Symbol	SMAD6
GeneID	4091
OMIM	602931
HGNC	6772
KEGG	hsa:4091
Ensembl	ENSG00000137834
String	9606.ENSP00000288840
Molecular Weight	53 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Mothers Against Decapentaplegic Homolog 6 (SMAD6)

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