Survival of Motor Neuron-Related-Splicing Factor 30 (SMNDC1) Antibody

SMNDC1 Antibody is a Rabbit Polyclonal antibody against SMNDC1. SPF30 (survival of motor neuron-related-splicing factor 30), also known as SMNDC1 (survival motor neuron domain containing 1) or SMNR (SMN-related protein), is an essential splicing factor required for spliceosome assembly that belongs to the SMN family. It contains one Tudor domain with significant similarity to SMN (Survival Motor Neuron) and is expressed in skeletal muscle, pancreas and heart, localizing to Cajal bodies and nuclear speckles. SPF30 plays an important role in spliceosome assembly and directly interacts with five U snRNPs. The loss of SPF30 causes spliceosome assembly to arrest at prespliceosomes (A complex). This supports a function for SPF30 in mediating the incorporation/recruitment of U4/U5/U6 tri-snRNP to the prespliceosome. In addition, the overexpression of SPF30 can lead to apoptosis.

Target	Survival of Motor Neuron-Related-Splicing Factor 30 (SMNDC1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-238 of human SMNDC1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O75940 (UniProt, ExPASy)
UniProt Secondary AC	B2RA27, D3DRB1, Q5T3K6
UniProt Entry Name	SPF30_HUMAN
Gene Symbol	SMNDC1
GeneID	10285
NCBI Accession	NP_005862.1
KEGG	hsa:10285
String	9606.ENSP00000358616
Molecular Weight	Calculated MW: 27 kDa Observed MW: 27 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Survival of Motor Neuron-Related-Splicing Factor 30 (SMNDC1)

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