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Survival of Motor Neuron-Related-Splicing Factor 30 (SMNDC1) Antibody

Catalogue No: abx000816
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Survival of Motor Neuron-Related-Splicing Factor 30 (SMNDC1) Antibody

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SMNDC1 Antibody is a Rabbit Polyclonal antibody against SMNDC1. SPF30 (survival of motor neuron-related-splicing factor 30), also known as SMNDC1 (survival motor neuron domain containing 1) or SMNR (SMN-related protein), is an essential splicing factor required for spliceosome assembly that belongs to the SMN family. It contains one Tudor domain with significant similarity to SMN (Survival Motor Neuron) and is expressed in skeletal muscle, pancreas and heart, localizing to Cajal bodies and nuclear speckles. SPF30 plays an important role in spliceosome assembly and directly interacts with five U snRNPs. The loss of SPF30 causes spliceosome assembly to arrest at prespliceosomes (A complex). This supports a function for SPF30 in mediating the incorporation/recruitment of U4/U5/U6 tri-snRNP to the prespliceosome. In addition, the overexpression of SPF30 can lead to apoptosis.

Target SMNDC1
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human SMNDC1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC O75940 (UniProt, ExPASy)
UniProt Secondary AC B2RA27, D3DRB1, Q5T3K6
UniProt Entry Name SPF30_HUMAN
Gene Symbol SMNDC1
GeneID 10285
KEGG hsa:10285
String 9606.ENSP00000358616
Molecular Weight Calculated MW: 26 kDa
Observed MW: 27 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Survival of Motor Neuron-Related-Splicing Factor 30 (SMNDC1) Antibody

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