Sphingomyelin Phosphodiesterase 2 (SMPD2) Antibody

SMPD2 Antibody is a Rabbit Polyclonal antibody against SMPD2. Sphingomyelinases (SMases) catalyze the hydrolysis of sphingomyelin to produce ceramide and phosphocholineCeramide is an important bioactive lipid triggering signal transduction involved in cell prolifeRation, apoptosis and differentiationA number of SMases have been described and categorized based on their optimum pH activity, cation dependence, tissue distribution, and subcellular localizationThese include a lysosomal acid SMase, a Zn++-dependent secreted acid SMase, a membrane-bound Mg++-dependent neutral SMase, a Mg++-independent neutral SMase, and an alkaline SMasenSMase1 (also termed SMPD2) is a Mg++-dependent neutral SMase that is widely expressed and predominantly localized to the endoplasmic reticulumThis protein has also been shown to have lyso-platelet activating factor (PAF) phospholipase C activityA second neutral SMase, nSMase2 (also termed SMPD3) is predominantly expressed in the brainThe activity of neutral SMases is regulated by oxidative stress, chemotherapeutic drugs, inflammatory cytokines, and apoptotic stimuliAnalysis of single and double knockouts of the SMPD2 and SMPD3 has revealed that loss of both genes leads to complete loss of neutral SMase activity with developmental defects observed with loss of nSMase2.

Target	Sphingomyelin Phosphodiesterase 2 (SMPD2)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant protein of human SMPD2.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O60906 (UniProt, ExPASy)
UniProt Secondary AC	Q5TED1, Q9BWR3
UniProt Entry Name	NSMA_HUMAN
Gene Symbol	SMPD2
GeneID	6610
KEGG	hsa:6610
String	9606.ENSP00000258052
Buffer	PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Sphingomyelin Phosphodiesterase 2 (SMPD2)

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