Snail Family Transcriptional Repressor 2 / SLUG (SNAI2) Antibody
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Catalogue No: abx012040
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US$427.75
(Size: 100 µl)
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Datasheet SDS
This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity.The tumor suppressor protein p53 induces Slug expression in gamma irradiated cells; Slug protects damaged cells from apoptosis by repressing p53-induced transcription of the proapoptotic Bcl-2 family protein Puma. Mutations in this gene may be associated with sporatic cases of neural tube defects.
Research Articles on Snail Family Transcriptional Repressor 2 / SLUG (SNAI2)
| Target | Snail Family Transcriptional Repressor 2 / SLUG (SNAI2) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human SNAI2 expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | O43623 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R6P6, Q53FC1 |
| UniProt Entry Name | SNAI2_HUMAN |
| Gene Symbol | SNAI2 |
| GeneID | 6591 |
| OMIM | 172800 |
| HGNC | 11094 |
| KEGG | hsa:6591 |
| Ensembl | ENSG00000019549 |
| String | 9606.ENSP00000380034 |
| Molecular Weight | 30 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |