Suppressor of Cytokine Signaling 1 (SOCS-1) Antibody

Suppressor of Cytokine Signaling 1 (SOCS-1) Antibody is a Rabbit Polyclonal antibody for the detection of SOCS1.

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN) -gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.

Target	Suppressor of Cytokine Signaling 1 (SOCS-1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	ELISA, WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Suppressor of cytokine signaling 1
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	O15524 (UniProt, ExPASy)
UniProt Secondary AC	O15097, Q9NSA7
UniProt Entry Name	SOCS1_HUMAN
Gene Symbol	SOCS1
GeneID	8651
OMIM	603597
HGNC	19383
KEGG	hsa:8651
Ensembl	ENSG00000185338
String	9606.ENSP00000329418
Molecular Weight	Observed MW: 24 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Suppressor of Cytokine Signaling 1 (SOCS-1)

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