Suppressors of Cytokine Signaling 3 (SOCS3) Antibody

SOCS3 Antibody is a Rabbit Polyclonal antibody against SOCS3. The suppressor of cytokine signaling (SOCS) family proteins are negative feedback system that inhibits cytokine signal transduction. One of the SOCS family, SOCS3, also named as CIS3 and SSI3, is involved in inhibition of JAK/STAT pathway which regulates IL-6 signaling in vivo. SOCS3 can be rapidly trigger by a number of factors including interleukins, IFN-gamma and TNF-alpha. Pathology such as inflammatory response, wound repair and obesity and so on have been linked to SOCS3. This antibody was raised against the full-length SOCS3 of human origin.

Target	Suppressors of Cytokine Signaling 3 (SOCS3)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 101-225 of human SOCS3.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O14543 (UniProt, ExPASy)
UniProt Secondary AC	O14509
UniProt Entry Name	SOCS3_HUMAN
Gene Symbol	SOCS3
GeneID	9021
NCBI Accession	NP_003946.3
KEGG	hsa:9021
String	9606.ENSP00000330341
Molecular Weight	Calculated MW: 25 kDa Observed MW: 26 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Suppressors of Cytokine Signaling 3 (SOCS3)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue