Sortilin Related Receptor (SORL1) Antibody

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Catalogue No: abx011546
Price: US$420.50
(Size: 100 µl)

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Datasheet SDS
SORL1 (sortilin-related receptor, L A repeats containing) also known as sorting protein-related receptor containing LDLR class A (SorLA), is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL and transports it into cells by endocytosis. SorLA is synthesized as a proreceptor which is processed to the mature form by a furin-like propeptidase. It can also bind to RAP (receptor-associated protein). SorLA is a multifunctional endocytis receptor important in lipoprotein and protease uptake. The N-terminal propeptide, which is removed, can be cleaved by furin or homologous proteases. Endogenous SorLA binds the neuropeptide head activator (HA) and is important for HA signaling and function. The gene encoding for the protein maps to chromosome 8p23.1. SorLA is expressed mainly in brain (cerebral cortex, cerebellum and the occipital pole), but can also be found in liver, spinal cord, kidney, testis and pancreas.

Target Sortilin Related Receptor (SORL1)
Clonality Monoclonal
Reactivity Human
Tested Applications ELISA, IHC, IF/ICC
Host Mouse
Recommended dilutions ELISA: 1/10000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Purified recombinant fragment of human SORL1 expressed in E. coli.
Isotype IgG1
Form Liquid
Purification Unpurified ascites.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q92673 (UniProt, ExPASy)
UniProt Secondary AC B2RNX7, Q92856
UniProt Entry Name SORL_HUMAN
Gene Symbol SORL1
GeneID 6653
OMIM 104300
HGNC 11185
KEGG hsa:6653
Ensembl ENSG00000137642
String 9606.ENSP00000260197
Molecular Weight 246 kDa
Buffer Ascitic fluid containing 0.03% sodium azide.
Concentration Not determined.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Sortilin Related Receptor (SORL1)


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