Serine/Threonine-Protein Kinase 39 (SPAK) Antibody

STK39 is a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress.

Target	Serine/Threonine-Protein Kinase 39 (SPAK)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 386-415 amino acids from the C-terminal region of human SPAK (STK39).
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9UEW8 (UniProt, ExPASy)
UniProt Secondary AC	O14774, Q53S90, Q53SL7, Q53SS1, Q9UER4, X5D9C8
UniProt Entry Name	STK39_HUMAN
NCBI Accession	NP_037365.2
String	9606.ENSP00000348278
Molecular Weight	Calculated MW: 59.5 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat STK39.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Serine/Threonine-Protein Kinase 39 (SPAK)

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