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Hyaluronidase PH-20 (SPAM1) Antibody

Catalogue No: abx001732
Price: £120.00
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Hyaluronidase PH-20 (SPAM1) Antibody Hyaluronidase PH-20 (SPAM1) Antibody

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SPAM1 Antibody is a Rabbit Polyclonal antibody against SPAM1. Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].

Target SPAM1
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 100-300 of human SPAM1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P38567 (UniProt, ExPASy)
UniProt Secondary AC Q8TC30
UniProt Entry Name HYALP_HUMAN
Gene Symbol SPAM1
GeneID 6677
NCBI Accession NP_003108.2
KEGG hsa:6677
String 9606.ENSP00000345849
Molecular Weight Calculated MW: 57 kDa, 58 kDa
Observed MW: 47 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration 3.94 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Hyaluronidase PH-20 (SPAM1) Antibody

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