Sphingosine Kinase 1 (SPHK1) Antibody

SPHK1 Antibody is a Rabbit Polyclonal antibody against SPHK1. The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Target	Sphingosine Kinase 1 (SPHK1)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 50-384 of human SPHK1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9NYA1 (UniProt, ExPASy)
UniProt Secondary AC	Q8N632, Q96GK1, Q9HD92, Q9NY70, Q9NYL3
Gene Symbol	SPHK1
GeneID	8877
NCBI Accession	NP_001136074.1
Molecular Weight	Calculated MW: 43 kDa Observed MW: 55 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Sphingosine Kinase 1 (SPHK1)

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