Sphingosine Kinase 2 (SPHK2) Antibody

SPHK2 Antibody is a Rabbit Polyclonal antibody against SPHK2. This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011].

Target	Sphingosine Kinase 2 (SPHK2)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-165 of human SPHK2.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9NRA0 (UniProt, ExPASy)
UniProt Secondary AC	A0T4C8, B4DU87, Q9BRN1, Q9H0Q2, Q9NWU7
UniProt Entry Name	SPHK2_HUMAN
Gene Symbol	SPHK2
GeneID	56848
NCBI Accession	NP_001191088.1
String	9606.ENSP00000245222
Molecular Weight	Calculated MW: 69 kDa Observed MW: 65 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Sphingosine Kinase 2 (SPHK2)

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