SPO11, Initiator of Meiotic Double Stranded Breaks (SPO11) Antibody

Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described.

Target	SPO11, Initiator of Meiotic Double Stranded Breaks (SPO11)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 299-326 amino acids from the C-terminal region of human SPO11.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9Y5K1 (UniProt, ExPASy)
UniProt Secondary AC	Q5TCI1, Q8N4V0, Q9NQM7, Q9NQM8
UniProt Entry Name	SPO11_HUMAN
Gene Symbol	SPO11
String	9606.ENSP00000360310
Molecular Weight	Calculated MW: 44.5 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on SPO11, Initiator of Meiotic Double Stranded Breaks (SPO11)

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