Osteopontin (SPP1) Antibody

The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene.

Target	Osteopontin (SPP1)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, IHC, IF/ICC
Host	Mouse
Recommended dilutions	ELISA: 1/10000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human SPP1 (AA: 167-314) expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Purified from ascites by Protein G chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P10451 (UniProt, ExPASy)
UniProt Entry Name	OSTP_HUMAN
Gene Symbol	SPP1
GeneID	6696
OMIM	166490
HGNC	11255
KEGG	hsa:6696
Ensembl	ENSG00000118785
String	9606.ENSP00000378517
Molecular Weight	35.4 kDa
Buffer	PBS, containing 0.05% sodium azide.
Concentration	1 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Osteopontin (SPP1)

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