Osteopontin (SPP1) Antibody

SPP1 Antibody is a Rabbit Polyclonal antibody against SPP1. Osteopontin (SPP1), also designated bone sialoprotein 1, urinary stone protein, spp-1, Eta-1, nephropontin and uropontin, is an extracellular matrix cell adhesion phosphoglycoprotein. SPP1 is deposited into unmineralized matrix prior to calcification leading to localization at various tissue interfaces including cement lines, lamina limitans and between collagen fibrils of fully matured hard tissues. While SPP1 is a major product of osteoblasts, it is also synthesized by brain and kidney cells. SPP1 isolated from or secreted by various tissues ranges in molecular weight due to posttranslational modifications. SPP1 functions as a substrate for transglutaminase and is involved in cell adhesion, chemoattraction and immunomodulation.

Target	Osteopontin (SPP1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/1000 - 1/5000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 17-314 of human Osteopontin.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P10451 (UniProt, ExPASy)
UniProt Entry Name	OSTP_HUMAN
Gene Symbol	SPP1
GeneID	6696
NCBI Accession	NP_001035147.1
KEGG	hsa:6696
String	9606.ENSP00000378517
Molecular Weight	Calculated MW: 35 kDa Observed MW: 45-70 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Osteopontin (SPP1)

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