Sterol Regulatory Element-Binding Protein 2 (SREBF2) Antibody

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Catalogue No: abx025838
Price: US$326.25
(Size: 80 µl)

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Sterol Regulatory Element-Binding Protein 2 (SREBF2) Antibody Sterol Regulatory Element-Binding Protein 2 (SREBF2) Antibody Sterol Regulatory Element-Binding Protein 2 (SREBF2) Antibody

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Datasheet SDS
SREBPs, including SREBP-1a, SREBP-1c, and SREBP-2, constitute a family of basic helix-loop-helix (bHLH) transcription factors that play a critical role in lipid homeostasis by regulating genes involved in cholesterol and fatty acid metabolism. Each SREBP consists of three domains, including an amino-terminal transcription factor domain of ~480 amino acids, a middle hydrophobic region of ~80 amino acids containing two hydrophobic transmembrane segments, and a carboxy-terminal regulatory domain of ~590 amino acids. SREBP-2 regulates cholesterol synthesis by activating the transcription of genes for HMG-CoA reductase and other enzymes of the cholesterol synthetic pathway. SREBP-2 is ubiquitously detected in various tissues. Under basal conditions SREBP is bound to ER membranes as a glycosylated precursor protein. Upon cholesterol depletion, the protein is cleaved to its active forms (about 50-68 kDa) and translocated into the nucleus to stimulate transcription of genes involved in the uptake and synthesis of cholesterol.

Target Sterol Regulatory Element-Binding Protein 2 (SREBF2)
Clonality Polyclonal
Reactivity Human
Tested Applications ELISA, WB, IHC, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/1000, IHC-P: 1/10 - 1/50, IF/ICC: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic peptide between 399-427 amino acids from the Central region of human SREBF2.
Isotype IgG
Form Liquid
Purification Purified through a protein A column, followed by peptide affinity purification.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q12772 (UniProt, ExPASy)
UniProt Secondary AC Q05BD5, Q6GTH7, Q86V36, Q9UH04
UniProt Entry Name SRBP2_HUMAN
KEGG hsa:6721
String 9606.ENSP00000354476
Molecular Weight Calculated MW: 124 kDa
Buffer PBS containing 0.09% sodium azide.
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on Sterol Regulatory Element-Binding Protein 2 (SREBF2)


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