STAM Binding Protein (STAMBP) Antibody

STAM Binding Protein (STAMBP) Antibody is a Rabbit Polyclonal antibody against STAMBP. STAMBP is a zinc metalloprotease that specifically cleaves Lys63-linked polyubiquitin chains but does not cleave Lys48-linked polyubiquitin chains. It plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. It potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. It has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. This protein also binds to the SH3 domain of the signal-transducing adaptor molecule required for induction of MYC and cell growth. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization. STAMBP is involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.

Target	STAM Binding Protein (STAMBP)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000 - 1/5000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant human STAM-binding protein (1-424AA).
Isotype	IgG
Form	Liquid
Purity	> 95%
Purification	Purified by Protein G.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O95630 (UniProt, ExPASy)
UniProt Secondary AC	B5M0B6, D6W5H7, Q3MJE7
UniProt Entry Name	STABP_HUMAN
Gene Symbol	STAMBP
GeneID	10617
OMIM	606247
NCBI Accession	NP_006454.1 NM_006463.4
KEGG	hsa:10617
String	9606.ENSP00000377633
Enzyme Commission Number	EC 3.1.2.15 EC 3.4.19.-
Buffer	0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on STAM Binding Protein (STAMBP)

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