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STAT1 (pY701) Antibody is a Rabbit Polyclonal antibody against STAT1 (pY701). Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-a and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.
Research Articles on STAT1 (pY701) Antibody
||Human, Mouse, Rat
||WB: 1/500 - 1/1000, IHC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
||Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding Y701 of human STAT1.
||Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
|UniProt Primary AC
||Calculated MW: 83 kDa, 87 kDa
Observed MW: 85 kDa
||PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
||> 1 mg/ml
||Shipped within 5-10 working days.
||This product is for research use only.