Signal Transducer and Activator of Transcription 2 Phospho-Tyr690 (STAT2 pY690) Antibody

STAT2 (pY690) Antibody is a Rabbit Polyclonal antibody against STAT2 (pY690). The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.

Target	Signal Transducer and Activator of Transcription 2 Phospho-Tyr690 (STAT2 pY690)
Clonality	Polyclonal
Target Modification	Tyr690
Modification	Phosphorylation
Reactivity	Human, Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/100 - 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic phosphorylated peptide around Y690 of human STAT2.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P52630 (UniProt, ExPASy)
UniProt Secondary AC	B4DLC7, G3V2M6, Q16430, Q16431, Q9UDL4
UniProt Entry Name	STAT2_HUMAN
Gene Symbol	STAT2
GeneID	6773
NCBI Accession	NP_005410.1
KEGG	hsa:6773
String	9606.ENSP00000315768
Molecular Weight	Calculated MW: 98 kDa Observed MW: 97 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Signal Transducer and Activator of Transcription 2 Phospho-Tyr690 (STAT2 pY690)

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