Signal Transducer and Activator of Transcription 3 Phospho-Tyr705 (STAT3 pY705) Antibody
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Catalogue No: abx031920
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US$326.25
(Size: 80 µl)
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Datasheet SDS
STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein.
Research Articles on Signal Transducer and Activator of Transcription 3 Phospho-Tyr705 (STAT3 pY705)
| Target | Signal Transducer and Activator of Transcription 3 Phospho-Tyr705 (STAT3 pY705) |
| Clonality | Polyclonal |
| Target Modification | Tyr705 |
| Modification | Phosphorylation |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y705 of human STAT3. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by protein G affinity chromatography. Then, the antibody fraction was peptide affinity purified in a 2-step procedure with control and phosphorylated peptides. The phospho-specific antibody was eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P40763 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K7B8, K7ENL3, O14916, Q9BW54 |
| UniProt Entry Name | STAT3_HUMAN |
| NCBI Accession | NP_003141.2 NP_644805.1 NP_998827.1 |
| KEGG | hsa:6774 |
| String | 9606.ENSP00000264657 |
| Molecular Weight | Calculated MW: 88.1 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse, Rat, Cow and Pig STAT3. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |