Signal Transducer and Activator of Transcription 3 Phospho-Tyr705 (STAT3 pY705) Antibody

Stat3 (pY705) Antibody is a Rabbit Polyclonal antibody against Stat3 (pY705). The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Target	Signal Transducer and Activator of Transcription 3 Phospho-Tyr705 (STAT3 pY705)
Clonality	Polyclonal
Target Modification	Tyr705
Modification	Phosphorylation
Reactivity	Human, Mouse
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/100 - 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic phosphorylated peptide around Y705 of human Phospho-STAT3-Y705.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P40763 (UniProt, ExPASy)
UniProt Secondary AC	A8K7B8, K7ENL3, O14916, Q9BW54
UniProt Entry Name	STAT3_HUMAN
Gene Symbol	STAT3
GeneID	6774
NCBI Accession	NP_644805.1
KEGG	hsa:6774
String	9606.ENSP00000264657
Molecular Weight	Calculated MW: 88 kDa Observed MW: 79/86 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Signal Transducer and Activator of Transcription 3 Phospho-Tyr705 (STAT3 pY705)

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