Signal Transducer and Activator of Transcription 3 Phospho-Tyr705 (STAT3 pY705) Antibody

Catalogue No: abx000144
Price: £120.00
(Size: 20 µl)
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Stat3 (pY705) Antibody is a Rabbit Polyclonal antibody against Stat3 (pY705). The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Target Signal Transducer and Activator of Transcription 3 Phospho-Tyr705 (STAT3 pY705)
Clonality Polyclonal
Target Modification Tyr705
Modification Phosphorylation
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding Tyr705 of human Stat3.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P40763 (UniProt, ExPASy)
UniProt Secondary AC A8K7B8, K7ENL3, O14916, Q9BW54
UniProt Entry Name STAT3_HUMAN
Gene Symbol STAT3
GeneID 6774
KEGG hsa:6774
String 9606.ENSP00000264657
Molecular Weight Calculated MW: 83 kDa, 87 kDa, 88 kDa
Observed MW: 105 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 0.5 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Signal Transducer and Activator of Transcription 3 Phospho-Tyr705 (STAT3 pY705)

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