Signal Transducer and Activator of Transcription 5A Phospho-Tyr694 (STAT5A pY694) Antibody
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Catalogue No: abx000190
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US$232.00
(Size: 20 µl)
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Datasheet SDS
STAT5A (pY694) Antibody is a Rabbit Polyclonal antibody against STAT5A (pY694). The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene.
Research Articles on Signal Transducer and Activator of Transcription 5A Phospho-Tyr694 (STAT5A pY694)
| Target | Signal Transducer and Activator of Transcription 5A Phospho-Tyr694 (STAT5A pY694) |
| Clonality | Polyclonal |
| Target Modification | Tyr694 |
| Modification | Phosphorylation |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic phosphorylated peptide around Y694 of human STAT5A. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P42229 (UniProt, ExPASy) |
| UniProt Secondary AC | Q1KLZ6 |
| UniProt Entry Name | STA5A_HUMAN |
| Gene Symbol | STAT5A |
| GeneID | 6776 |
| NCBI Accession | NP_001275647.1 |
| KEGG | hsa:6776 |
| String | 9606.ENSP00000341208 |
| Molecular Weight | Calculated MW: 91 kDa Observed MW: 90 kDa |
| Buffer | PBS, pH 7.3, containing 0.09% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |