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Signal Transducer and Activator of Transcription 5A Phospho-Tyr694 (STAT5A pY694) Antibody

Catalogue No: abx000190
Price: £120.00
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Signal Transducer and Activator of Transcription 5A Phospho-Tyr694 (STAT5A pY694) Antibody

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STAT5A (pY694) Antibody is a Rabbit Polyclonal antibody against STAT5A (pY694). The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene.

Target Signal Transducer and Activator of Transcription 5A Phospho-Tyr694 (STAT5A pY694)
Clonality Polyclonal
Reactivity Human
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding Y694 of human STAT5A.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P42229 (UniProt, ExPASy)
UniProt Secondary AC Q1KLZ6
UniProt Entry Name STA5A_HUMAN
Gene Symbol STAT5A
GeneID 6776
KEGG hsa:6776
String 9606.ENSP00000341208
Molecular Weight Calculated MW: 86 kDa, 90 kDa
Observed MW: 105 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Signal Transducer and Activator of Transcription 5A Phospho-Tyr694 (STAT5A pY694) Antibody

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