Signal Transducer And Activator of Transcription 5B (STAT5b) Antibody

STAT5b is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.

Target	Signal Transducer And Activator of Transcription 5B (STAT5b)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 760-787 amino acids from the C-terminal region of human STAT5b.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P51692 (UniProt, ExPASy)
UniProt Secondary AC	Q8WWS8
UniProt Entry Name	STA5B_HUMAN
NCBI Accession	NP_036580.2
KEGG	hsa:6777
String	9606.ENSP00000293328
Molecular Weight	Calculated MW: 89.9 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Cow and Pig STAT5B.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Signal Transducer And Activator of Transcription 5B (STAT5b)

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