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Signal Transducer And Activator of Transcription 5B (STAT5B) Antibody

Catalogue No: abx000660
Price: £120.00
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Signal Transducer And Activator of Transcription 5B (STAT5B) Antibody

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STAT5B Antibody is a Rabbit Polyclonal antibody against STAT5B. The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.

Target STAT5B
Clonality Polyclonal
Reactivity Human, Rat
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/20 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human STAT5B.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P51692 (UniProt, ExPASy)
UniProt Secondary AC Q8WWS8
UniProt Entry Name STA5B_HUMAN
Gene Symbol STAT5B
GeneID 6777
String 9606.ENSP00000293328
Molecular Weight Calculated MW: 89 kDa
Observed MW: 95 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Signal Transducer And Activator of Transcription 5B (STAT5B) Antibody

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