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Signal Transducer And Activator of Transcription 5B (STAT5B) Antibody
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Catalogue No: abx000660
Price:
US$377.00
(Size: 60 µl)
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STAT5B Antibody is a Rabbit Polyclonal antibody against STAT5B. The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
Research Articles on Signal Transducer And Activator of Transcription 5B (STAT5B)
| Target | Signal Transducer And Activator of Transcription 5B (STAT5B) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/100, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human STAT5B |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P51692 (UniProt, ExPASy) |
| UniProt Secondary AC | Q8WWS8 |
| UniProt Entry Name | STA5B_HUMAN |
| Gene Symbol | STAT5B |
| GeneID | 6777 |
| NCBI Accession | NP_036580.2 |
| KEGG | hsa:6777 |
| String | 9606.ENSP00000293328 |
| Molecular Weight | Calculated MW: 89 kDa Observed MW: 92 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
