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Signal Transducer And Activator of Transcription 5B (STAT5B) Antibody

Catalogue No: abx000660
Price: £95.00
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Signal Transducer And Activator of Transcription 5B (STAT5B) Antibody

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STAT5B Antibody is a Rabbit Polyclonal antibody against STAT5B. The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.

Target STAT5B
Reactivity Human, Rat
Host Rabbit
Clonality Polyclonal
Tested Applications WB, IF/ICC
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/20 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Immunogen Recombinant protein of human STAT5B.
Purification Affinity purified.
Form Liquid
Isotype IgG
Conjugation Unconjugated
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Molecular Weight Calculated MW: 89 kDa
Observed MW: 95 kDa
Swiss Prot P51692
GeneID 6777
Gene Symbol STAT5B
Concentration > 1 mg/ml
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
UNSPSC Code 12352203
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Signal Transducer And Activator of Transcription 5B (STAT5B) Antibody

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