SUMO1 Antibody is a Rabbit Polyclonal antibody against SUMO1. Small ubiquitin-related modifier 1, 2 and 3 (SUMO-1, -2 and -3) are members of the ubiquitin-like protein familyThe covalent attachment of the SUMO-1, -2 or -3 (SUMOylation) to target proteins is analogous to ubiquitinationThis post-translational modification is a reversible, multi-step process that is initiated by cleaving a precursor protein to a mature proteinMature SUMO-1, -2 or -3 is then linked to the activating enzyme E1, conjugated to E2 and in conjunction with E3, SUMO-1, -2 or -3 is ligated to the target proteinUbiquitin and the individual SUMO family members are all targeted to different proteins with diverse biological functionsUbiquitin predominantly regulates degradation of its targetIn contrast, SUMO-1 is conjugated to RanGAP, PML, p53 and IκB-α to regulate nuclear trafficking, formation of subnuclear structures, regulation of transcriptional activity and protein stabilitySUMO-2/-3 forms poly-(SUMO) chains, is conjugated to topoisomerase II and APP, regulates chromosomal segregation and cellular responses to environmental stress, and plays a role in the progression of Alzheimer disease.
Target |
Small Ubiquitin Related Modifier Protein 1 (SUMO1) |
Clonality |
Polyclonal |
Reactivity |
Human, Mouse, Rat |
Tested Applications |
ELISA, WB, IHC, IF/ICC, FCM, IP |
Host |
Rabbit |
Recommended dilutions |
WB: 1/500 - 1/2000, IHC: 1/20 - 1/200, ICC: 1/50 - 1/200, IP: 1/20 - 1/50, FCM: 1/20 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
Conjugation |
Unconjugated |
Immunogen |
A synthetic peptide of human SUMO-1. |
Isotype |
IgG |
Form |
Liquid |
Purification |
Purified by affinity chromatography. |
Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
UniProt Primary AC |
P63165 (UniProt,
ExPASy)
|
UniProt Secondary AC |
A8MUS8, B2R4I5, P55856, Q6FGG0, Q6NZ62, Q93068 |
UniProt Entry Name |
SUMO1_HUMAN |
Gene Symbol |
SUMO1 |
GeneID |
7341
|
KEGG |
hsa:7341
|
String |
9606.ENSP00000376077
|
Buffer |
PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
Availability |
Shipped within 5-10 working days. |
Note |
This product is for research use only. |
Research Articles on Small Ubiquitin Related Modifier Protein 1 (SUMO1)