E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

Catalogue No: abx002034
Price: £120.00
(Size: 20 µl)
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E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

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SYVN1 Antibody is a Rabbit Polyclonal antibody against SYVN1. HRD1is also named as SYVN1(Synovial apoptosis inhibitor 1), KIAA1810. It acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Two distinct binding sites mediate Hrd1 dimerization or oligomerization, one located within the transmembrane region and another within the cytosolic domain. (PMID:19864457).Western blot analysis detected abundant HRD1 expression in liver and kidney. Mouse liver and spleen expressed Hrd1 as an 85-kD protein(PMID:12646171).This antibody is specific to HRD1.

Target SYVN1
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein of human SYVN1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q86TM6 (UniProt, ExPASy)
UniProt Secondary AC Q8N3K3, Q8N6E8, Q96JL5, Q96PK3
UniProt Entry Name SYVN1_HUMAN
Gene Symbol SYVN1
GeneID 84447
KEGG hsa:84447
String 9606.ENSP00000366395
Molecular Weight Calculated MW: 61 kDa, 67 kDa
Observed MW: 72 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody

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