TGF-Beta-Activated Kinase 1 And MAP3K7-Binding Protein 2 (TAB2) Antibody

The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappa B and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.

Target	TGF-Beta-Activated Kinase 1 And MAP3K7-Binding Protein 2 (TAB2)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human TAB2 expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9NYJ8 (UniProt, ExPASy)
UniProt Secondary AC	B2RCC4, E1P5A0, O94838, Q6I9W8, Q76N06, Q9UFP7
UniProt Entry Name	TAB2_HUMAN
Gene Symbol	TAB2
GeneID	23118
OMIM	605101
HGNC	17075
Ensembl	ENSG00000055208
String	9606.ENSP00000356426
Molecular Weight	80 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on TGF-Beta-Activated Kinase 1 And MAP3K7-Binding Protein 2 (TAB2)

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