TAR DNA-Binding Protein 43 / TDP43 (TARDBP) Antibody
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Catalogue No: abx001097
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US$217.50
(Size: 20 µl)
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Datasheet SDS
TARDBP Antibody is a Rabbit Polyclonal antibody against TARDBP. HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.
Research Articles on TAR DNA-Binding Protein 43 / TDP43 (TARDBP)
| Target | TAR DNA-Binding Protein 43 / TDP43 (TARDBP) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC, IP |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200, IP: 0.5 µg - 4 µg antibody per 200 µg - 400 µg extracts of whole cells, RIP: 1/20 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant protein corresponding to TARDBP. The exact sequence is proprietary. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q13148 (UniProt, ExPASy) |
| UniProt Secondary AC | A4GUK4, A4GUK5, A4GUK6, B2R629, B4DJ45, E2PU12, Q53H27, Q6FI92, Q96DJ0 |
| UniProt Entry Name | TADBP_HUMAN |
| Gene Symbol | TARDBP |
| GeneID | 23435 |
| OMIM | 605078 |
| NCBI Accession | NP_031401.1 |
| HGNC | 11571 |
| KEGG | hsa:23435 |
| Ensembl | ENSG00000120948 |
| String | 9606.ENSP00000240185 |
| Molecular Weight | Calculated MW: 45 kDa Observed MW: 42 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |