TAR DNA-Binding Protein 43 / TDP43 (TARDBP) Antibody

TARDBP Antibody is a Rabbit Polyclonal antibody against TARDBP. HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.

Target	TAR DNA-Binding Protein 43 / TDP43 (TARDBP)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB, IP
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IP: 0.5-4 µg/200-400 µg whole cell extracts, RIP: 1/20 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human TDP-43/TARDB.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q13148 (UniProt, ExPASy)
UniProt Entry Name	TADBP_HUMAN
Gene Symbol	TARDBP
GeneID	23435
NCBI Accession	NP_031401.1
KEGG	hsa:23435
String	9606.ENSP00000240185
Molecular Weight	Calculated MW: 45 kDa Observed MW: 42 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on TAR DNA-Binding Protein 43 / TDP43 (TARDBP)

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