TANK-Binding Kinase 1 (TBK) Antibody

The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. TKB is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK.

Target	TANK-Binding Kinase 1 (TBK)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/2000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 150-181 amino acids from human TBK.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9UHD2 (UniProt, ExPASy)
UniProt Secondary AC	A8K4S4, Q8IYV3, Q9NUJ5
UniProt Entry Name	TBK1_HUMAN
NCBI Accession	NP_037386.1
String	9606.ENSP00000329967
Molecular Weight	Calculated MW: 83.6 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Zebrafish and Xenopus TBK1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on TANK-Binding Kinase 1 (TBK)

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