Transcription Factor E2-Alpha (TCF3) Antibody
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Catalogue No: abx010676
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US$427.75
(Size: 100 µl)
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Datasheet SDS
E2A is a transcription factor that plays major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Heterodimers between E2A and tissue-specific basic helix-loop-helix (bHLH) Dimers bind DNA on E-box motifs: 5'- CANNTG-3'. Binds to the kappa -E2 site in the kappa immunoglobulin gene enhancer. Deletions in E2A have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Two alternatively spliced human isoforms have been described.
Research Articles on Transcription Factor E2-Alpha (TCF3)
| Target | Transcription Factor E2-Alpha (TCF3) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, FCM |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, WB: 1/500 - 1/2000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human TCF3 expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P15923 (UniProt, ExPASy) |
| UniProt Secondary AC | P15883, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9 |
| UniProt Entry Name | TFE2_HUMAN |
| Gene Symbol | TCF3 |
| GeneID | 6929 |
| OMIM | 147141 |
| HGNC | 11633 |
| KEGG | hsa:6929 |
| Ensembl | ENSG00000071564 |
| String | 9606.ENSP00000262965 |
| Molecular Weight | 67.6 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |