Tryptophan 2,3-Dioxygenase (TDO2) Antibody

TDO2 Antibody is a Rabbit Polyclonal antibody against TDO2. This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism.

Target	Tryptophan 2,3-Dioxygenase (TDO2)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/1000 - 1/5000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 100-200 of human TDO2.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P48775 (UniProt, ExPASy)
UniProt Secondary AC	A8K053
UniProt Entry Name	T23O_HUMAN
Gene Symbol	TDO2
GeneID	6999
NCBI Accession	NP_005642.1
KEGG	hsa:6999
String	9606.ENSP00000444788
Molecular Weight	Calculated MW: 48 kDa Observed MW: 48 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Tryptophan 2,3-Dioxygenase (TDO2)

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