Telomeric Repeat-Binding Factor 1 (TERF1) Antibody

TERF1 Antibody is a Rabbit Polyclonal antibody against TERF1. Telomeres are nucleoprotein complexes located at chromosome ends that consist of tandem arrays of TTAGGG repeats bound to specific proteins. Telomeres protect chromosome ends from degradation and end-to-end fusions, prevent activation of DNA damage checkpoints, and modulate the maintenance of telomeric DNA by telomerase. TERF1 (telomeric repeat-binding factor 1) binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. It's one component of the shelterin complex, which involved in the regulation of telomere length and protection.

Target	Telomeric Repeat-Binding Factor 1 (TERF1)
Clonality	Polyclonal
Reactivity	Human, Rat
Tested Applications	WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 52-275 of human TERF1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P54274 (UniProt, ExPASy)
UniProt Secondary AC	A7XP29, Q15553, Q8NHT6, Q93029
UniProt Entry Name	TERF1_HUMAN
Gene Symbol	TERF1
GeneID	7013
OMIM	600951
NCBI Accession	NP_059523.2
HGNC	11728
KEGG	hsa:7013
Ensembl	ENSG00000147601
String	9606.ENSP00000276603
Molecular Weight	Calculated MW: 50 kDa Observed MW: 50 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Telomeric Repeat-Binding Factor 1 (TERF1)

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