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Telomerase Reverse Transcriptase (TERT) Antibody
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Catalogue No: abx002167
Price:
£120.00
(Size: 20 µl)
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TERT Antibody is a Rabbit Polyclonal antibody against TERT. Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks.
Research Articles on TERT
| Target | TERT |
| Clonality | Polyclonal |
| Reactivity | Human, Rat |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic peptide of human TERT. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O14746 (UniProt, ExPASy) |
| UniProt Secondary AC | O14783, Q2XS35, Q8N6C3, Q8NG38, Q8NG46 |
| Gene Symbol | TERT |
| GeneID | 7015 |
| OMIM | 178500 |
| NCBI Accession | NP_001180305.1 NM_001193376.1 |
| HGNC | 11730 |
| KEGG | hsa:7015 |
| Ensembl | ENSG00000164362 |
| String | 9606.ENSP00000309572 |
| Molecular Weight | Calculated MW: 88 kDa, 90 kDa, 120 kDa, 126 kDa Observed MW: 125 kDa |
| Buffer | PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.5 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |
