Telomerase Reverse Transcriptase (TERT) Antibody

Catalogue No: abx002167
Price: £120.00
(Size: 20 µl)

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Datasheet SDS
TERT Antibody is a Rabbit Polyclonal antibody against TERT. Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks.

Target TERT
Clonality Polyclonal
Reactivity Human, Rat
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide of human TERT.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC O14746 (UniProt, ExPASy)
UniProt Secondary AC O14783, Q2XS35, Q8N6C3, Q8NG38, Q8NG46
Gene Symbol TERT
GeneID 7015
OMIM 178500
NCBI Accession NP_001180305.1 NM_001193376.1
HGNC 11730
KEGG hsa:7015
Ensembl ENSG00000164362
String 9606.ENSP00000309572
Molecular Weight Calculated MW: 88 kDa, 90 kDa, 120 kDa, 126 kDa
Observed MW: 125 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 0.5 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on TERT

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