Methylcytosine Dioxygenase TET1 (TET1) Antibody

TET1 Antibody is a Rabbit Polyclonal antibody against TET1. TET1 (tet oncogene 1), also known as LCX or CXXC6, is a 2,136 amino acid protein that localizes to the nucleus and contains one CXXC-type zinc finger. Expressed in adult ovary, thymus and skeletal muscle and also present in fetal lung, heart and brain, TET1 is thought to play a role in the development of fetal organs and may also be involvement in the pathoegenesis and metastasis of acute myeloid leukemia (AML). The gene encoding TET1 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.

Target	Methylcytosine Dioxygenase TET1 (TET1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 1800-1900 of human TET1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q8NFU7 (UniProt, ExPASy)
UniProt Secondary AC	Q5VUP7, Q7Z6B6, Q8TCR1, Q9C0I7
UniProt Entry Name	TET1_HUMAN
Gene Symbol	TET1
GeneID	80312
OMIM	607790
NCBI Accession	NP_085128.2
KEGG	hsa:80312
String	9606.ENSP00000362748
Molecular Weight	Calculated MW: 235 kDa Observed MW: 250 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	1.16 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Methylcytosine Dioxygenase TET1 (TET1)

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