Transcription Factor AP-2 Alpha (TFAP2A) Antibody

TFAP2A is a sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limbs and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. TFAP2A is the only AP-2 protein required for early morphogenesis of the lens vesicle.

Target	Transcription Factor AP-2 Alpha (TFAP2A)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 407-436 amino acids from the C-terminal region of human TFAP2A.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P05549 (UniProt, ExPASy)
UniProt Secondary AC	Q13777, Q5TAV5, Q8N1C6
UniProt Entry Name	AP2A_HUMAN
KEGG	hsa:7020
String	9606.ENSP00000368924
Molecular Weight	Calculated MW: 48.1 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Cow TFAP2A.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Transcription Factor AP-2 Alpha (TFAP2A)

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