Transferrin Receptor Protein 1 / CD71 (TFRC) Antibody
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Catalogue No: abx025453
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US$326.25
(Size: 80 µl)
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Datasheet SDS
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
Research Articles on Transferrin Receptor Protein 1 / CD71 (TFRC)
| Target | Transferrin Receptor Protein 1 / CD71 (TFRC) |
| Research Area | Signal Transduction, Cellular Differentiation and Adhesion, Tumor Immunity, Infection Immunity, Cancer |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Mouse |
| Recommended dilutions | WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 649-677 amino acids from human TFRC. |
| Isotype | IgM |
| Form | Liquid |
| Purification | Purified Mouse Monoclonal Antibody. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P02786 (UniProt, ExPASy) |
| UniProt Secondary AC | D3DXB0, Q1HE24, Q59G55, Q9UCN0, Q9UCU5, Q9UDF9, Q9UK21 |
| UniProt Entry Name | TFR1_HUMAN |
| KEGG | hsa:7037 |
| String | 9606.ENSP00000353224 |
| Molecular Weight | Calculated MW: 84.9 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |