Transforming Growth Factor Beta 1 (TGFb1) Antibody
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Catalogue No: abx012041
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US$152.25
(Size: 35 µg)
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Datasheet SDS
This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
Research Articles on Transforming Growth Factor Beta 1 (TGFb1)
| Target | Transforming Growth Factor Beta 1 (TGFb1) |
| Research Area | Cytokines, Tumor Immunity, Infection Immunity, Cancer |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, IHC, FCM |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human TGFb1 (AA: 62-195) expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Purified from ascites by Protein G chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P01137 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K792, Q9UCG4 |
| UniProt Entry Name | TGFB1_HUMAN |
| Gene Symbol | TGFB1 |
| GeneID | 7040 |
| OMIM | 131300 |
| HGNC | 11766 |
| KEGG | hsa:7040 |
| Ensembl | ENSG00000105329 |
| String | 9606.ENSP00000221930 |
| Molecular Weight | 44.3 kDa |
| Buffer | PBS, containing 0.05% sodium azide. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |