Transforming Growth Factor Beta Receptor 2 (TGFBR2) Antibody

TGFBR2 Antibody is a Rabbit Polyclonal antibody against TGFBR2. This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.

Target	Transforming Growth Factor Beta Receptor 2 (TGFBR2)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 23-280 of human TGF beta Receptor II (TGFBR2).
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P37173 (UniProt, ExPASy)
UniProt Secondary AC	B4DTV5, Q15580, Q6DKT6, Q99474
UniProt Entry Name	TGFR2_HUMAN
Gene Symbol	TGFBR2
GeneID	7048
NCBI Accession	NP_003233.4
KEGG	hsa:7048
String	9606.ENSP00000351905
Molecular Weight	Calculated MW: 65 kDa Observed MW: 70/65/85 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Transforming Growth Factor Beta Receptor 2 (TGFBR2)

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