Protein-Glutamine Gamma-Glutamyltransferase 2 (TGM2) Antibody

TGM2 Antibody is a Rabbit Polyclonal antibody against TGM2. Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene.

Target	Protein-Glutamine Gamma-Glutamyltransferase 2 (TGM2)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 299-548 of human Transglutaminase 2 (TGM2).
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P21980 (UniProt, ExPASy)
UniProt Secondary AC	E1P5V9, Q16436, Q6B838, Q9BTN7, Q9H035, Q9UH35
UniProt Entry Name	TGM2_HUMAN
Gene Symbol	TGM2
GeneID	7052
NCBI Accession	NP_945189.1
KEGG	hsa:7052
String	9606.ENSP00000355330
Molecular Weight	Calculated MW: 77 kDa Observed MW: 77 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	1.16 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Protein-Glutamine Gamma-Glutamyltransferase 2 (TGM2)

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