THO Complex 6 (THOC6) Antibody

Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing-and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1. UAP56 functions as a bridge between THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and THOC4.

Target	THO Complex 6 (THOC6)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 96-123 amino acids from the Central region of human THOC6.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q86W42 (UniProt, ExPASy)
UniProt Secondary AC	B2RA85, Q8NBR1, Q9BTV9
UniProt Entry Name	THOC6_HUMAN
Gene Symbol	THOC6
KEGG	hsa:79228
String	9606.ENSP00000326531
Molecular Weight	Calculated MW: 37.5 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat THOC6.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on THO Complex 6 (THOC6)

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