Thyroid Hormone Receptor Beta (THRB) Antibody

THRB Antibody is a Rabbit Polyclonal antibody against THRB. The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008].

Target	Thyroid Hormone Receptor Beta (THRB)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-263 of human TRβ1/THRB.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P10828 (UniProt, ExPASy)
UniProt Secondary AC	B3KU79, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
UniProt Entry Name	THB_HUMAN
Gene Symbol	THRB
GeneID	7068
NCBI Accession	NP_000452.2
KEGG	hsa:7068
String	9606.ENSP00000379904
Molecular Weight	Calculated MW: 53 kDa Observed MW: 53 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	0.91 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Thyroid Hormone Receptor Beta (THRB)

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