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Tight Junction Protein ZO-1 (TJP1) Antibody

Catalogue No: abx000800
£120.00 £80.00
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Tight Junction Protein ZO-1 (TJP1) Antibody

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TJP1 Antibody is a Rabbit Polyclonal antibody against TJP1 (ZO1). Tight junctions, or zona occludens, form a continuous barrier to fluids across the epithelium and endothelium. They function in regulation of paracellular permeability and in the maintenance of cell polarity, blocking the movement of transmembrane proteins between the apical and the basolateral cell surfaces (reviewed in 1). Zona occludens proteins ZO-1, -2, and -3 (also known as TJP1, 2, and 3) are peripheral membrane adaptor proteins that link junctional transmembrane proteins such as occludin and claudin to the actin cytoskeleton (reviewed in 2). ZO-1 and -2 are required for tight junction formation and function (3,4). In subconfluent proliferating cells, ZO-1 and ZO-2 have been shown to colocalize to the nucleus and play a role in transcriptional regulation, possibly through facilitating nuclear import/export of transcriptional regulators (5-7). The ZO-2 gene is transcribed from two promoters, generating the ZO-2A and ZO-2C isoforms. ZO-2C lacks a 23 amino acid amino-terminal sequence found in other ZO-2 isoforms. While both isoforms appear to be widely expressed, abnormal regulation of the ZO-2 gene may be correlated with development of ductal cancer (8).

Target Tight Junction Protein ZO-1 (TJP1)
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/200 - 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein of human ZO1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q07157 (UniProt, ExPASy)
UniProt Secondary AC B4E3K1, Q2NKP3, Q4ZGJ6
UniProt Entry Name ZO1_HUMAN
Gene Symbol TJP1
GeneID 7082
KEGG hsa:7082
String 9606.ENSP00000281537
Molecular Weight Calculated MW: 186 kDa, 195 kDa
Observed MW: 250 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration 1.26 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Tight Junction Protein ZO-1 (TJP1) Antibody

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