Metalloproteinase Inhibitor 2 (TIMP2) Antibody

TIMP2 Antibody is a Rabbit Polyclonal antibody against TIMP2. This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.

Target	Metalloproteinase Inhibitor 2 (TIMP2)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 50-150 of human TIMP2.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P16035 (UniProt, ExPASy)
UniProt Secondary AC	Q16121, Q93006, Q9UDF7
UniProt Entry Name	TIMP2_HUMAN
Gene Symbol	TIMP2
GeneID	7077
NCBI Accession	NP_003237.2
KEGG	hsa:7077
String	9606.ENSP00000262768
Molecular Weight	Calculated MW: 24 kDa Observed MW: 24 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	1.36 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Metalloproteinase Inhibitor 2 (TIMP2)

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